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    • CBD: An Introduction to Cannabidiol & The Benefits

      Scientists are rapidly discovering more and more about the rather amazing abilities of the cannabinoids found in the #cannabis plant. Most of them have shown therapeutic value, as have the terpenes, which give the plant its distinct odors. There are over 125 #terpenes and over 80 cannabinoids in cannabis and each #strain has its own unique blend that create its distinct effects. CBD is just one cannabinoid. #Cannabinoids are 21-carbon molecules that block or stimulate endocannabinoid receptors. It’s known that other cannabinoids, such as #THC, THCV, #CBN and CBD, bind to CB1 and/or CB2 receptors, just as do the brain’s own naturally occurring cannabinoids – AEA and 2 AG. Many of these cannabinoids have therapeutic value and #CBD is no exception. It is a non-psychotropic #cannabinoid, meaning it does not contribute to the euphoria associated with certain strains of cannabis. It is, however, psychoactive, because it crosses the blood-brain barrier. Unlike THC, CBD can be administered at relatively high doses without undesired psychological side effects. "The big selling point for the surging popularity of CBD has been that it is non-euphoric." CBD also has the effect of reducing the undesirable effects of high-THC cannabis, such as anxiety and paranoia, which allows a #patient to ingest more THC, which has its own incredible medical effects. CBD is a powerful anti-epileptic, anti-depressant, anti-inflammatory, anti-nauseate, sleep aid, muscle relaxant, sedative and anti-proliferative. What’s in A Name? The federal government seems schizophrenic when it comes to CBD. Some interpret the government’s position to mean CBD is legal if it comes from #hemp, despite hemp, cannabis and #marijuana all being the exact same thing. We should not be surprised. An odd distinction existed from 1916 until 1942 where what you called the plant made the difference between cannabis being legal and marijuana being illegal. Marijuana was illegal in most states but cannabis was not only legal in all states, but widely prescribed by physicians and available in over twenty-five over-the-counter medicines. The marijuana laws were more often applied to Hispanics and African Americans while Anglo-Caucasian and other pharmacy cannabis customers could obtain the #medicinal cannabis with impunity. The federal government has patented CBD. Here is what they say in their patent abstract: Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as #Alzheimer’s disease, #Parkinson’s disease and #HIV dementia. Nonpsychoactive cannabinoids, such as #cannabidiol, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cananbinoids useful as neuroprotective antioxidants is formula (1) wherein the R group is independently selected from the group consisting of H, CH3 and COCH3. The big selling point for the surging popularity of CBD has been that it is non-euphoric. The idea that using medication to feel #good is not appropriate, unusual or unacceptable seems to almost uniquely apply to cannabis. Tranquilizers, antidepressants and ED medicines are all intended to make us feel emotionally better, even #euphoric. While some may not want the euphoria associated with THC and other euphorogenic constituents of the plant, there is the therapeutic consideration of the benefit of using the whole plant (the entourage effect). As with any therapeutic agent the physician will weigh the balance of the therapeutic effects to the side effects. Entourage Effect Many clinicians believe that using CBD as an isolated compound not only diminishes its therapeutic value but does not take full advantage of the medicinal value of cannabis. This is because of the entourage effect, the concept that the totality of the therapeutic constituents of the plant acting together are more effective than any single isolated compound acting alone. The federal government promotes the concept that “Single-molecule pharmaceuticals are superior to ‘crude’ whole plant medicinals.” Here’s what Martin Lee, author of ‘Smoke Signals’ and ‘Acid Dreams’ had to say about this issue: “According to the federal government, specific components of the marijuana plant (THC, CBD) have medical value, but the plant itself does not have medical value. Uncle Sam’s single-molecule blinders reflect a cultural and political bias that privileges Big Pharma products. Single-molecule medicine is the predominant corporate way, the FDA-approved way, but it’s not the only way, and it’s not necessarily the optimal way to benefit from cannabis therapeutics. Cannabis contains several hundred compounds, including various #flavonoids, aromatic terpenes, and many minor cannabinoids in addition to THC and CBD. Each of these compounds has specific healing attributes, but when combined they create what scientists refer to as a holistic “entourage effect,” so that the therapeutic impact of the whole plant is greater than the sum of its single-molecule parts. The Food and Drug administration, however, isn’t in the business of approving plants as medicine. [See the scientific evidence].” Route of Administration When looking at the effects of cannabis we need to be cognizant that different routes of cannabinoid administration have different effects. Inhaled THC enters capillaries in the lungs, passes into general circulation through the pulmonary arteries and goes directly to the brain without passing through the liver. The cannabinoids then cross the blood-brain barrier to affect the #endocannabinoid #receptors. In addition, when cannabis is burned new compounds are created not found in the raw or dried plant. The respiratory route of administration allows THC and other constituents of the plant to go directly to the brain without going through the liver. THC metabolites contribute significantly to the effects of cannabis consumption. On the first pass through the liver, 85% of THC is metabolized. Some of it is metabolized to 11-hydrox-THC, a THC metabolite that activates CB1 cannabinoid receptors in the brain. It induces a high more potently than THC itself. When ingested orally, however, THC and other cannabinoids and terpenes are absorbed from the small intestine over several hours. THC and the other constituents are then carried to the liver, where THC is metabolized by subclasses of cytochrome P450 enzyme (abbreviated CYP), specifically the CYP2C and CYP3A enzymes. About 85% of the THC is metabolized on its first pass through the liver. Like any oral medication, it will take about 45-75 minutes before enough of the plant constituents are in the bloodstream to exert a therapeutic effect. Further, there will be a greater effect of a THC metabolic breakdown product, 11-hydroxy-THC. Terpenes, Cannabinoids and The Endocannabinoid System (ECS) Let’s be very clear. All plants are chemically complex, containing hundreds of different molecules. A tomato has about 380 different molecules. Coffee 880. Cannabis 512. Of these 512 compounds, 80-100 are cannabinoids and over 125 are terpenes. Many of these chemicals have therapeutic value. The ECS is the largest neurotransmitter system in the brain. It can be affected by both exogenous (from outside the body) and endogenous (from inside the body) cannabinoids that exert their many pharmacological effects. Dr. Raphael Mechoulam, the researcher who first isolated and identified THC in 1964, also helped characterize the ECS system in 1992. There are at least two types of cannabinoid receptors in mammalian tissues, dubbed CB1 and CB2 receptors. CB1 receptors are not only in the brain and spinal cord but in peripheral tissues as well. CB2 receptors are found primarily in immune tissues. It is quite likely that in the near future, research will identify more components of the ECS. Epilepsy In early 2014, a CNN documentary by Sanjay Gupta, M.D. pointed out the anti-epileptic properties of cannabis. He focused on a young child who had intractable seizures. Several years earlier, Dr. Mechoulam described an experiment by Paul F. Consroe and colleagues in Brazil where CBD was tested as a treatment for intractable epilepsy. Patients stayed on the anticonvulsants they had been on, which hadn’t eliminated their seizures, and added 200 mg/day of CBD or a placebo. The subjects were followed over the course of several months. Mechoulam noted that of the seven patients getting CBD; three became seizure-free; one experienced only one or two seizures; and two experienced reduced severity and occurrence of seizures. Only one showed no improvement. CBD is one of the reasons that cannabis has been known for centuries as an anti-seizure medicine. Now in the second decade of the twenty-first century, there is increased public interest in this therapeutic property of cannabis. As a side note, earlier this year Brazil approved the use of CBD to treat epilepsy. Prescribing is restricted to psychiatrists and neurologists. Neuroprotective There have been numerous studies that demonstrate cannabis’ neuroprotective capabilities. Cannabinoids help preserve brain matter in stroke and traumatic brain injury. Studies have shown that cannabidiol (CBD) at a concentration of 10 uM, was neuroprotective against both excitatory transmitter (glutamate) and oxidant (hydroperoxide) induced neurotoxicity. Mechoulam developed a synthetic cannabinoid, dextranabinol, that has been shown in basic science studies to help limit brain tissue death from decreased tissue oxygenation. This can be caused by stroke, traumatic brain injury (TBI), or being placed on a heart-lung machine during cardiac bypass surgery. "Earlier this year Brazil approved the use of CBD to treat epilepsy. Prescribing is restricted to psychiatrists and neurologists." Post-traumatic stress disorder (PTSD) Mechoulam has characterized post-traumatic stress disorder, certain phobias and forms of chronic pain as human situations which are conditioned and might be amenable to treatment with CBD. “I know that many patients with #PTSD take cannabis, self-administered,” Mechoulam said. The Israeli Ministry of Health has tested CBD and THC at various ratios to treat PTSD. They currently have a successful program at Abarbanal Hospital in Israel where cannabis is used to treat PTSD. Cannabinoids, Tumors and Cancer Cannabis has been shown in both tissue culture and mice to be effective at inhibiting the growth of many cancers. CBD plays an important role in that effort. Other cannabinoids also contribute to cannabis’ anti-neoplastic (anti-cancer) effect. Cannabis is an anti-oxidant. Antioxidants have been shown to decrease the incidence of #cancer. There are several mechanisms for this anti-cancer effect: cannabis affects a gene which controls metastasis so it decreases metastasis, encourages apoptosis (death of old or abnormal cells), and inhibits angiogenesis (formation of new blood vessels). In 1974, a research team at the Medical College of Virginia (acting at the behest of the federal government) discovered that cannabis inhibited malignant tumor cell growth in cell culture and in mice. This is the study that was published in the above referenced Journal of the National Cancer Institute in 1975, According to the study’s results, reported nationally in an August 18, 1974 Washing Post newspaper feature, administration of marijuana’s primary cannabinoid THC, “slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent.” “During times of universal deceit, telling the truth becomes a revolutionary act.” ― attributed to George Orwell, British author, 1903-1950 #CBD #Cancertreatment

    • DYI: Smoking with Fruits and Veggies

      Whether you're in a tight pinch with nothing to #smoke out of or you're just looking to channel a little creativity, these #fruits & #veggies can be a fun flavorful way to #consumecannabis. First were going to go over some handy tools you may have lying around your house. Then we'll cover how to make a #pipe out of everything from Apples to Zucchini. STEP 1: Gather the #Tools Sculpting tools: 1. Chopsticks/Skewers Great for puncturing to create an airway for your smoke to travel through. 2. Sharp Knife For cutting or slicing through some of the tougher areas. 3. Hollow Pen Can be used like a skewer 4. Small Spoon Great for scooping out placement of a bowl after a cut has been made STEP 2: #Produce the #Pipe Now that you have your tools, lets get started! Make sure you have some napkins and foil although not necessary. Apple: This a pretty straightforward one. What your going to want to do is remove the stem, then take your spoon or knife and carve a bowl shape into the top, then poke a little hole in the bottom with your skewer you want the hole to reach the apples core. Next take your pen shell and push it through the side of the apple, intersecting with the core. Leave the pen inside a little bit so you have a straw to inhale through. Pack your dankies in the top Light up and take off! Banana: This pipe is definitely sure to blow some minds. First what your going to want to do is take your sharp knife, n' cut off an inch of the end opposite of the long stem.  This is going to be your bowl piece, hollow out the banana leaving a bowl shaped peel. set this aside for now. Next, take the bigger half of your banana and push a hole into the middle of the open end. making sure not to poke a hole all the way through. make another hole on the side of the banana intersecting with the tunnel you've made, this is where your bowl piece will go. Now take the banana carve out a little slot for the bowl piece you just made, just enough to make it nice and snug. Make sure your bowl has a hole at the bottom. Once its all together, pack that sticky icky and toke away. Avocado: Similar to the other fruits, Poke a hole at the top of the avocado (the skinny part), going into to the center. Next, make a small finger size cut on the side, which will be your carb. Finally, make another hole on the top of the avocado, which will be the bowl area. If you need to pack more herb in your pipe, add in another avocado. Make the second avocado into a bowl extension like the bananas, which will let you pack more bud. Put this piece into the bowl area, and toke up. Pear: Similar to the apple, the pear makes a great easy smoking utensil. Master the recipe for the apple pipe, and the pear will be yours for the taking. Jalapeno: In a quick pinch when you just need a #chillum, this spicy bad boy is the hero that saves the day! Rip off the stem, poke a whole through the center, bite the tip, make sure there's a tunnel and pack your herb. BOOM! A quick spicy solution to a stoners tight situation. Zucchini: The Zucchini makes for a great #steamroller, easy to tunnel through, and easy to find in a large enough size. This pipe beats a water bottle any day. Crafted like the banana, this pipe you're going to want to cut off an end, to fashion a bowl piece. Next create a tunnel through the zucchini making sure not to poke through the opposite end. Now make an incision from the opposite end, scoop some of the Zucchini out, make a nice tight fit for your bowl piece. Should be a sufficient device to take some fat rips. Remember, the possibilities are endless! With a little creativity, you can make a #pipe or #bong with virtually anything!

    • Cutting Through the Haze - A Frank Talk about Cannabis in Canada

      It was the kind of conversation that would have been unimaginable only five years ago. On the 16th floor of a gleaming office tower in the heart of Toronto’s financial district, in a meeting room at one of Canada’s most respected public affairs firms, a mixture of millennials and grey haired boomers gathered over wine and canapés to listen to a thoughtful discussion about smoking marijuana. The event, Up in Smoke-Marijuana: The Good, the Bad and the Uncertain, could not have been more topical. It came only days after the federal government unveiled its legislation to legalize cannabis. The changing landscape is sparking the growth of a new industry, one that Deloitte estimates could be worth $22 billion. But it is also raising a multitude of questions about how Canadian society will adapt. Up in Smoke was part of a series of events sponsored by Women’s Brain Health Initiative (WBHI) under our Millennial Minds™ program. The goal is to send a message that brain health is not only something that older people should be thinking about—it is just as important for millennials to consider as well. The discussion was hosted by public affairs firm Navigator, which has been at the forefront of the debate, offering both counsel and analysis on the marijuana file to a variety of clients. Managing Partner Will Stewart acted as MC, noting that he is getting calls all the time asking whether the folks at Navigator are smoking up in the office. And he is regularly teased. “Willy’s the weed guy,” he said, to titters from the audience. But it was a serious and enlightening evening, featuring commentary from experts in medicine, the law and the emerging cannabis industry. Dr. Mark Ware of McGill University is a renowned researcher in medical marijuana and was the co-chair of the recent task force on cannabis, whose report was influential in the drafting of the new legislation. He told the audience that he believes that legalization will make it easier for researchers to explore new therapeutic uses for cannabinoids—the chemicals that are unique to cannabis. The best-known use for medical marijuana is pain relief, for which it has been legally prescribed for years, but Dr. Ware said we are only beginning to understand other possible benefits, such as the treatment of some of the most disturbing symptoms of dementia. “Pain is the way in but there are a huge number of potential therapies,” he said. He also pointed out that marijuana seems to affect men and women differently—women have been shown to be more susceptible to the effects whereas men are more likely to develop dependencies. Dr. Ware expressed the hope that amid the many millions of dollars currently being invested in the commercial exploitation of cannabis that some money might be set aside to support research. Although cannabis is an ancient product that has already been studied extensively, there was a consensus on the panel that the Canadian public needs to know much more about it—in effect to become more knowledgeable consumers. That is the role that a new firm called Lift hopes to play. It describes itself as “the meeting place for cannabis in Canada.” Lift CEO Matei Olaru was an Up in Smoke panelist, saying: “there’s not a lack of information (about marijuana) but an overabundance of misinformation.” He said there is a huge need for education for the new, legal “recreation market”. “Lift hopes to fill the gap…we are all about empowering consumers.” In fact, as I learned during the discussion, there are dozens of different forms of cannabis, which can have wildly varying effects on the user. Here is where the product differs from beer, wine or spirits. But Alison Gordon, VP of Marketing and Communications for Delshen Therapeutics (which is in the medical marijuana sphere), said that the government’s proposed restrictions on advertising will make it harder for buyers to educate themselves. “Marketing and branding is how people can make informed decisions. If we don’t allow licensed producers to create brands and market themselves, it’ll be harder to eliminate the black market because people want to know what they’re buying,” she said. During the question and answer portion of the event, a mother raised concerns about potential harmful effects, having seen one of her children experience a psychotic episode after using marijuana. Dr. Ware responded that he has heard many of these kinds of stories and warned that the cannabis industry ignores them at its peril. He believes legalization can help. “The problem is that you have the black market waiting to prey on 18-25 year olds (the largest group of users). If we make it illegal, they’ll get it anyway. But if we can educate them to use lower THC products, then at least they’ll know what they’re using,” he said. Up in Smoke covered a vast amount of ground over the evening. Employment lawyer Shelley Brown predicted that employers will need to develop policies to cover cannabis-related issues in the workplace. Aaron Salz, the CEO of the Stoic Advisory, a consultancy that specializes in financial issues for the new industry, observed that where once it was difficult for marijuana startups to raise money, investment is now pouring in. We heard about the retail experience from Alan Gertner, the CEO of Tokyo Smoke, which already has two outlets in Toronto and plans to open more across the country. He said customers come from out of town to his store “so they can buy from someone they can trust, in a safe place.” I must thank both Navigator and Brain Canada for their generous sponsorship of Up in Smoke. A central element of WBHI’s mandate is knowledge dissemination and I believe we all learned a great deal. It was so encouraging to see so many millennials in attendance—clearly this is a subject of great relevance for them, as it is for those of us from an older generation. The #legalization of cannabis is already sparking an important national conversation. I hope WBHI and our partners in staging Up in Smoke played a small role in shedding light on the many and varied implications of this new era. #CannabisCananda #MarijuanaLegalization #CannabisToday

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    • Cannabis Deals, Coupons and Savings | Marijuana Delivery

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    • Understanding Recreational vs. Medical Cannabis Laws in California

      Medical Limits & Requirements 18+ Valid ID Rec/MMIC 8ounces Dry Flower 8ounces Concentrates 8am-10pm Delivery Read More! Recreational 21+ Valid ID 28.5% Tax Limits & Requirements 28.5grams Dry Flower 8grams Concentrates 8am-10pm Delivery Read More! Medical Use California currently allows 2 types of Medical Use patients. To be a medical marijuana patient in the State of California, you must either obtain a: ​ a physician’s recommendation, also known as a Doctor's Recommendation or Doctor's Referral ​ ​ identification card issued by the Department of Health, also known as an MMIC ​ Is there a difference in an MMIC and Doctor's Rec? ​ Yes there is! Let's break it down... Where to Purchase and Consume? Marijuana can be purchased from a storefront or a delivery service, depending on local laws. California has placed time restrictions on what times legal retailers can dispense cannabis goods from 6am to 10pm. We here at California Green Cross deliver cannabis from the hours of 8am to 10pm to the greater Sacramento Area! See our delivery zone map if you want to check if you are within our delivery zone! Don't fall into our zone? No worries, the has a licensed dispensary search available for all cannabis consumers of California! Educate yourself on the difference in counterfeit cannabis products and licensed cannabis products; . Bureau of Cannabis Control (BCC) #weedwise (BCC) ​ ​ ​ "Weed is legal now, I can light up a blunt anywhere I want" FALSE ​ Just because marijuana is legal in California, does not mean you can consume it wherever you want! Just like alcohol, cannabis can not be consumed in public places. As a matter of fact, smoking, eating or ingesting marijuana is still illegal to consume in public. Marijuana must be consumed in a private place. ​ ​ The Different Types of Cannabis Products Flowers Flower is the most popular for cannabis consumers. Want something quick & on the go? Try a ! preroll Edibles Edibles, which come in many forms from baked goods to beverages, are a popular way to consume without smoking Concentrates Looking for a something heavier? Concentrates may be just for you! Vape or add them to your flower. CBD All the healing, no high! CBD compound is non psychoactive and has many great healing properties. Other Cannabis goods come in many other forms, including , , & more! topicals tinctures cartridges

    • Give5Get5 - PROMO | Cgc3

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